Ekuqaleni kuka-2025, abaphandi abavela kwiDyunivesithi yaseWashington kunye neBrigham kunye neSibhedlele sabasetyhini (isibhedlele sokufundisa kwiSikolo sezoNyango saseHarvard) baveze indlela engazange ibonwe ngaphambili yokunyanga isifo i-Alzheimer's - ukuphefumla.xenonigesi, engathinteli kuphela i-neuroinflammation kunye nokunciphisa i-brain atrophy, kodwa inyusa i-neuronal state ekhuselayo.

Xenonkunye Neuroprotection

Isifo sika-Alzheimer sesona sifo sixhaphakileyo kwi-neurodeergenerative ebantwini, kwaye unobangela waso kukholelwa ukuba unxulumene nokuqokelelwa kweprotein ye-tau kunye ne-beta-amyloid kwingqondo. Nangona kukho iziyobisi ezizama ukususa ezi proteni zinetyhefu, azizange zisebenze ekunciphiseni ukuqhubeka kwesi sifo. Ngoko ke, unobangela oyintloko wesi sifo nonyango aluqondwa ngokupheleleyo.

Uphononongo lubonise ukuba ukuphefumlaxenoninokuwela umqobo wegazi-ingqondo kwaye iphucule kakhulu imeko yeempuku kunye neemodeli zesifo se-Alzheimer phantsi kweemeko zelabhoratri.Uvavanyo lwahlulahlulwe lwaba ngamaqela amabini, elinye iqela leempuku libonise i-tau protein accumulation kwaye elinye iqela lineprotein ye-beta-amyloid. Iziphumo zovavanyo zibonise ukuba i-xenon ayizange yenze iimpuku zisebenze ngakumbi, kodwa iphinde yakhuthaza impendulo yokukhusela ye-microglia, eyimfuneko ekucoceni i-tau kunye ne-beta-amyloid proteins.

Oku kubhaqwa okutsha kuyinoveli kakhulu, ebonisa ukuba iziphumo ze-neuroprotective zinokuveliswa ngokulula ngokuphefumla irhasi engasebenziyo. Umda omkhulu kwicandelo lophando lwe-Alzheimer kunye nonyango kukuba kunzima kakhulu ukuyila amachiza anokuthi awele umqobo wegazi-ingqondo, kwayexenoningakwenza oku.

Ezinye izicelo zonyango ze-xenon

1. I-anesthesia kunye ne-analgesia: Njengegesi efanelekileyo yokuthomalalisa,xenonisetyenziswa ngokubanzi ngenxa yokungeniswa kwayo ngokukhawuleza kunye nokubuyiswa kwayo, ukuzinza okulungileyo kwe-cardiovascular kunye nomngcipheko ophantsi wemiphumo emibi;

2. Impembelelo ye-Neuroprotective: Ukongeza kwimpembelelo enokubakho yonyango kwi-Alzheimer's disease ekhankanywe ngasentla, i-xenon nayo ifundwe ukunciphisa umonakalo wengqondo obangelwa yi-neonatal hypoxic-ischemic encephalopathy (HIE);

3. Utyalo-mzimba kunye nokhuseleko:Xenoninokunceda ukukhusela amalungu omnikeli kwingozi ye-ischemia-reperfusion, ebaluleke kakhulu ekuphuculeni izinga lempumelelo yokutshintshwa;

4. I-Radiotherapy sensitization: Ezinye izifundo zokuqala zibonise ukuba i-xenon inokukwazi ukwandisa uvakalelo lwamathumba kwi-radiotherapy, enika isicwangciso esitsha sonyango lomhlaza;